Wolf's interest in physics began as a child when he viewed a newsreel depicting the world's first atomic explosion. Wolf received his Ph.D. in theoretical physics from UCLA in 1963 and began researching the field of high atmospheric particle behavior following a nuclear explosion.
Dr. Wolf has appeared as the resident physicist on the Discovery Channel program The Know Zone, was a participant in the PBS series Closer to Truth, and has appeared on radio talk shows and television shows across the United States and abroad. Wolf also appeared in the films What the#$*! Do We Know!? (2004), The Secret (2006) and Spirit Space (2008). He has lectured on subjects related to quantum physics and consciousness since the 1960s, often under the name Dr. Quantum or Captain Quantum. He is also featured in the documentary about the Dalai Lama entitled Dalai Lama Renaissance, which is narrated by Harrison Ford.
His book "Taking the Quantum Leap: The New Physics for Nonscientists" won the National Book Award as science paperback for 1980 from the National Book Foundation.
Wolf has taught at San Diego State University, the University of Paris, the Hebrew University of Jerusalem, the University of London, and Birkbeck College. He is sometimes criticized for blending verifiable scientific evidence for quantum phenomena with unfalsifiable metaphysical connections, often without differentiating between the two.